Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145495 | 0.74 | RAB9A (0.65) | NPC1RAB9ASMN1; SMN2TP53THRB | |
| SCHEMBL10351392 | 0.71 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2TP53HPGD | |
| SCHEMBL7470030 | 0.69 | RAB9A (1.00) | PKMNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1565989 | 0.69 | NPC1 (0.53) | PKMNPC1RAB9ASMN1; SMN2TP53 | |
| Trifluoromethylbenzene SCHEMBL10351140 | 0.68 | LMNA (0.57) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL26502086 | 0.67 | PKM (0.65) | PKMNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1340286 | 0.67 | AURKA (0.60) | PKMNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1565385 | 0.67 | NPC1 (0.59) | PKMNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL20887927 | 0.67 | LMNA (0.75) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL21237720 | 0.67 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0141713-B1 | Process for preparation of 2-substituted quinoline-3- carboxamides | ROUSSEL-UCLAF (FR) | 1990-05-30 | — | — | EP | disclosed |