Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282842 | 0.98 | ALDH1A1 (0.46) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL23151890 | 0.94 | ALDH1A1 (0.46) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL1613295 | 0.89 | USP2 (0.50) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL2766649 | 0.88 | KDM4E (0.52) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL2766162 | 0.86 | KDM4E (0.56) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL2766625 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL17657944 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL17658001 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL20879049 | 0.80 | LMNA (0.41) | ALDH1A1KDM4EUSP2LMNAMMP9 | |
| SCHEMBL4317153 | 0.80 | KDM4E (0.41) | ALDH1A1KDM4EUSP2LMNAMMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240254089-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | INCYTE CORPORATION | 2024-08-01 | — | — | US | disclosed |
| US-11773078-B2 | Furin inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-10-03 | — | — | US | disclosed |
| EP-4213839-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-07-26 | — | — | EP | disclosed |
| CN-116438162-A | Modulators of MAS-related G protein receptor X4 and related products and methods | 伊赛恩特制药公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022061008-A2 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-03-24 | — | — | WO | disclosed |
| WO-2021107047-A1 | METHOD FOR PRODUCING 4-(AMINOMETHYL)CYCLOHEXANE CARBOXYLIC ACID | 株式会社ＤＮＰファインケミカル | 2021-06-03 | — | — | WO | disclosed |
| WO-2021057190-A1 | QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海阳帆医药科技有限公司 | 2021-04-01 | — | — | WO | disclosed |
| US-20160355475-A1 | NOVEL INDOLE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2016-12-08 | — | — | US | disclosed |
| EP-2278653-B1 | NON-AQUEOUS SOLVENT AND NON-AQUEOUS ELECTROLYTE FOR AN ELECTRICITY STORAGE DEVICE, NON-AQUEOUS ELECTRICITY STORAGE DEVICE EMPLOYING THE SAME, SUCH AS LITHIUM SECONDARY BATTERY OR ELECTRIC DOUBLE-LAYER CAPACITOR | PANASONIC CORP (JP) | 2014-03-05 | — | — | EP | disclosed |
| CN-102138246-B | Nonaqueous solvent and nonaqueous electrolyte for electricity storage device, and electricity storage device, lithium secondary battery, and electric double layer capacitor each comprising same | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD | 2013-12-11 | — | — | CN | disclosed |
| EP-1627871-A1 | CYCLIC AMINOPHENYL SULFAMATE DERIVATIVE | Teikoku Hormone Mfg. Co., Ltd. (JP) | 2006-02-22 | — | — | EP | disclosed |
| US-6730784-B2 | AS THERAPEUTIC AGENTS FOR AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| US-20020198376-A1 | Novel urea derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-26 | — | — | US | disclosed |
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | disclosed |
| EP-1072591-A1 | NOVEL UREA DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2001-01-31 | — | — | EP | disclosed |
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-4661506-A | CARDIOVASCULAR AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0183238-A2 | 7-Oxabicycloheptane substituted oxa prostaglandin analogs | E.R. Squibb & Sons, Inc. (US) | 1986-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240254089-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X4 AND RELATED PRODUCTS AND METHODS | MRGPRX4, MRGPRX1, MRGPRX2 | ALDH1A1 4632/4885KDM4E 3303/4885USP2 3705/4885 |
| US-20020198376-A1 | Novel urea derivatives | TNF, CTH, CFH | ALDH1A1 1309/4885KDM4E 2856/4885USP2 163/4885 |
| US-11773078-B2 | Furin inhibitors | FURIN, TGFB1, PCSK7 | ALDH1A1 3733/4885KDM4E 4275/4885USP2 1985/4885 |
| US-20160355475-A1 | NOVEL INDOLE DERIVATIVE COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | HDAC2, HDAC1, HDAC3 | ALDH1A1 910/4885KDM4E 209/4885USP2 2177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.