Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.44 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.44 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.44 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.44 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.44 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.44 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | MPL | P40238 | 2/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10354781 | 0.97 | APP (0.52) | APPMPLKIF11PIM3PIM1 | |
| SCHEMBL8019910 | 0.84 | APP (0.63) | APPMPLKIF11PIM3PIM1 | |
| SCHEMBL1887694 | 0.78 | SRC (0.61) | APPMPLKIF11PIM3PIM1 | |
| SCHEMBL30143007 | 0.78 | SRC (0.61) | APPMPLKIF11PIM3PIM1 | |
| Acetone SCHEMBL8600747 | 0.78 | APP (0.55) | APPMPLKIF11PIM3PIM1 | |
| SCHEMBL11442193 | 0.77 | EGFR (0.57) | APPMPLPARP14MAPTJAK2 | |
| SCHEMBL6707468 | 0.75 | MPL (0.58) | APPMPLKIF11PIM3PIM1 | |
| SCHEMBL10868141 | 0.75 | APP (0.46) | APPMPLKIF11PIM3PIM1 | |
| SCHEMBL11425277 | 0.73 | MEN1 (0.60) | PARP14MAPTKDM4E | |
| Acetic Acid SCHEMBL11537832 | 0.72 | MPL (0.51) | APPMPLKIF11PIM3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0247479-B1 | PROCESS FOR THE PREPARATION OF THE SODIUM SALT OF 2-HYDROXYCARBAZOLE-1-CARBOXYLIC ACID | BAYER AG (DE) | 1990-08-08 | — | — | EP | claimed |
| EP-0247479-A1 | Process for the preparation of the sodium salt of 2-hydroxycarbazole-1-carboxylic acid | BAYER AG (DE) | 1987-12-02 | — | — | EP | disclosed |