Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10355308 | 0.99 | CYP1A2 (0.53) | CYP1A2CYP2C19CYP3A4CYP2D6L3MBTL1 | |
| SCHEMBL10355416 | 0.89 | MAPT (0.42) | CYP1A2CYP2C19CYP3A4CYP2D6L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10355378 | 0.88 | MAPT (0.41) | CYP1A2CYP2C19CYP3A4CYP2D6L3MBTL1 | |
| SCHEMBL10355369 | 0.82 | DHPS (0.48) | L3MBTL1GAAMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10355415 | 0.81 | DHPS (0.47) | L3MBTL1GAAMAPTMEN1KMT2A | |
| SCHEMBL10355266 | 0.80 | SLC2A1 (0.42) | CYP1A2CYP2C19MEN1KMT2ANPSR1 | |
| SCHEMBL10999375 | 0.79 | MAPK13 (0.48) | CYP1A2CYP3A4GAAMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL10355348 | 0.79 | SLC2A1 (0.41) | CYP1A2CYP2C19MEN1KMT2ANPSR1 | |
| SCHEMBL10355386 | 0.73 | ALDH1A1 (0.44) | CYP1A2CYP2C19CYP2D6L3MBTL1MAPT | |
| SCHEMBL7041734 | 0.68 | KDM4E (0.67) | KDM4ECCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | claimed |
| EP-0074130-B1 | NEW IMIDAZOLE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZAMBON S.p.A. (IT) | 1990-09-19 | — | — | EP | disclosed |
| US-4560696-A | Analgesic, antipyretic or anti-inflammatory imidazole compounds | ZAMBON S.P.A. (IT) | 1985-12-24 | — | — | US | disclosed |
| EP-0074130-A2 | New imidazole compounds, process for the preparation thereof and pharmaceutical compositions containing them | ZAMBON S.p.A. (IT) | 1983-03-16 | — | — | EP | disclosed |