Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 11/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.36 |
| ▸ | GLRB | P48167 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11603987 | 0.88 | ALOX15 (0.55) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL10356706 | 0.82 | VCAM1 (0.44) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9350056 | 0.81 | VCAM1 (0.43) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9484852 | 0.80 | ALOX15 (0.50) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL10677513 | 0.80 | VCAM1 (0.42) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9384054 | 0.79 | ALOX15 (0.49) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9735154 | 0.78 | VCAM1 (0.48) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9328163 | 0.78 | HPN (0.47) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL10685089 | 0.77 | ALOX15 (0.53) | VCAM1MAPTHPNALOX15SIRT5 | |
| SCHEMBL9119059 | 0.73 | MAPT (0.53) | VCAM1MAPTHPNALOX15SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235575-B1 | NOVEL PHENOLIC THIOETHERS AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1990-09-19 | — | — | EP | disclosed |
| EP-0235575-A1 | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1987-09-09 | — | — | EP | disclosed |