Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | TAS1R3 | Q7RTX0 | 9/20 | 0.65 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.65 |
| ▸ | TAS1R2 | Q8TE23 | 7/20 | 0.65 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29771924 | 0.86 | TAS1R3 (0.67) | HTTTAS1R3TAS1R1TAS1R2HSD17B2 | |
| SCHEMBL10462960 | 0.82 | TAS1R3 (0.62) | TAS1R3TAS1R1TAS1R2HSD17B2 | |
| SCHEMBL10464517 | 0.81 | HTT (0.60) | HTTTAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL2406255 | 0.80 | HTT (1.00) | HTTTAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL5436807 | 0.80 | HTT (1.00) | HTTTAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL10464516 | 0.79 | PTGIR (0.58) | HTTTAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL701253 | 0.79 | TAS1R3 (1.00) | TAS1R3TAS1R1TAS1R2HSD17B2ALDH1A1 | |
| SCHEMBL10463186 | 0.78 | HTT (0.55) | HTTTAS1R3TAS1R1TAS1R2LMNA | |
| SCHEMBL4278160 | 0.77 | TAS1R3 (0.55) | TAS1R3TAS1R1TAS1R2HSD17B2 | |
| SCHEMBL10463185 | 0.77 | TAS1R3 (0.56) | HTTTAS1R3TAS1R1TAS1R2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0253257-B1 | SUBSTITUTED AMINO-5,6,7,8-TETRAHYDRONAPHTHYL-OXYACETIC ACIDS, METHOD FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | BAYER AG (DE) | 1990-11-14 | — | — | EP | disclosed |
| US-4921998-A | ANTICOAGULANTS, ANTIISCHEMIC AGENTS, ATHEROSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 1990-05-01 | — | — | US | disclosed |
| US-4868331-A | ANTICOAGULANTS, ANTIATHEROSCLEROTIC, ANTIISCHEMIC | BAYER AKTIENGESELLSCHAFT (DE) | 1989-09-19 | — | — | US | disclosed |
| EP-0253257-A2 | Substituted amino-5,6,7,8-tetrahydronaphthyl-oxyacetic acids, method for their preparation and their application as medicaments | BAYER AG (DE) | 1988-01-20 | — | — | EP | disclosed |