Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10360467 | 0.86 | HRH3 (0.50) | LTA4HPTGS1PTGS2HRH3HRH1 | |
| SCHEMBL519769 | 0.82 | ALK (0.44) | LTA4HPTGS1PTGS2HRH3ABCB1 | |
| SCHEMBL76551 | 0.80 | LTA4H (0.69) | LTA4HPTGS1PTGS2HRH3PSMB1 | |
| SCHEMBL56495 | 0.79 | LTA4H (0.90) | LTA4HPTGS1PTGS2HRH3PSMB1 | |
| SCHEMBL8790607 | 0.79 | ABCB1 (0.78) | ABCB1 | |
| SCHEMBL23724061 | 0.78 | LTA4H (0.87) | LTA4HPTGS1PTGS2HRH3PSMB1 | |
| Hydrochloric Acid SCHEMBL15254264 | 0.78 | LTA4H (0.87) | LTA4HPTGS1PTGS2HRH3PSMB1 | |
| SCHEMBL3937460 | 0.78 | LTA4H (0.87) | LTA4HPTGS1PTGS2HRH3PSMB1 | |
| SCHEMBL10361498 | 0.77 | SIGMAR1 (0.53) | HRH3ABCB1 | |
| SCHEMBL1957333 | 0.76 | PNMT (0.45) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284384-B1 | ANTI-ARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-11-28 | — | — | EP | claimed |
| EP-0284384-A1 | Anti-arrhythmic agents | Pfizer Limited (GB) | 1988-09-28 | — | — | EP | claimed |
| EP-0284384-B1 | ANTI-ARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4891372-A | Antiarrhythmic agents, compositions and method of use thereas | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0284384-A1 | Anti-arrhythmic agents | Pfizer Limited (GB) | 1988-09-28 | — | — | EP | disclosed |