Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CALCA | P06881 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921149 | 0.84 | MAOA (0.48) | PLAUDRD2KCNH2KDM4ELMNA | |
| SCHEMBL6229471 | 0.83 | LMNA (0.50) | PLAUKCNH2KDM4ELMNAPOLB | |
| SCHEMBL2926351 | 0.83 | ALDH1A1 (0.47) | PLAUDRD2KCNH2KDM4ELMNA | |
| SCHEMBL6965488 | 0.82 | MEN1 (0.45) | DRD2KCNH2KDM4EFAAHMCHR1 | |
| SCHEMBL1352039 | 0.81 | MAPT (0.55) | PLAUKDM4EMCHR1MAPT | |
| SCHEMBL6232343 | 0.76 | MCHR1 (0.48) | DRD2KDM4ELMNAFAAHMCHR1 | |
| SCHEMBL10365458 | 0.76 | ALDH1A1 (0.46) | LMNAHTR1ASLC6A4 | |
| SCHEMBL5764654 | 0.74 | MCHR1 (0.49) | DRD2KDM4EFAAHMCHR1MEN1 | |
| SCHEMBL10364802 | 0.74 | CYP2D6 (0.47) | DRD2KCNH2FAAHHTR2CMCHR1 | |
| SCHEMBL6234696 | 0.74 | MAPT (0.41) | PLAUKDM4ELMNAPOLBCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0285323-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-11-28 | — | — | EP | claimed |
| EP-0285323-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-10-05 | — | — | EP | claimed |
| EP-0285323-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4822793-A | Benzazepine antiarrhythmic agents | PFIZER INC. (US) | 1989-04-18 | — | — | US | disclosed |
| EP-0285323-A1 | Antiarrhythmic agents | Pfizer Limited (GB) | 1988-10-05 | — | — | EP | disclosed |