Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921149 | 0.82 | MAOA (0.48) | MCHR1DRD2DRD3KDM4EFAAH | |
| SCHEMBL1352039 | 0.81 | MAPT (0.55) | MCHR1KDM4EMAPTGAASMN1; SMN2 | |
| SCHEMBL6229471 | 0.81 | LMNA (0.50) | MCHR1KDM4EFAAHMAPTLMNA | |
| SCHEMBL2926351 | 0.81 | ALDH1A1 (0.47) | MCHR1DRD2DRD3KDM4EFAAH | |
| SCHEMBL5764654 | 0.80 | MCHR1 (0.49) | MCHR1DRD4DRD2DRD3KDM4E | |
| SCHEMBL6231291 | 0.80 | ALDH1A1 (0.53) | MCHR1ALDH1A1LMNAMAPK1 | |
| SCHEMBL10364825 | 0.76 | PLAU (0.41) | MCHR1DRD2DRD3KDM4EFAAH | |
| SCHEMBL8319517 | 0.74 | FAAH (0.51) | DRD4DRD2DRD3KDM4EFAAH | |
| SCHEMBL8323715 | 0.74 | SLC6A4 (0.54) | DRD4DRD2DRD3KDM4EFAAH | |
| SCHEMBL8323587 | 0.73 | HTR1A (0.55) | DRD4DRD2DRD3KDM4EFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |