Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 9/20 | 0.34 |
| ▸ | DRD4 | P21917 | 9/20 | 0.34 |
| ▸ | DRD3 | P35462 | 9/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | DRD5 | P21918 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685328 | 0.82 | CYP26A1 (0.50) | HTR1ASIGMAR1DDB1CRBN | |
| SCHEMBL10685155 | 0.80 | S1PR1 (0.40) | HTR1ASIGMAR1DDB1CRBNFFAR1 | |
| Englitazone SCHEMBL4727851 | 0.79 | PPARG (0.50) | FFAR1 | |
| Englitazone SCHEMBL29377687 | 0.79 | PPARG (0.50) | FFAR1 | |
| Englitazone SCHEMBL20125579 | 0.79 | PPARG (0.50) | FFAR1 | |
| Englitazone SCHEMBL37697 | 0.79 | PPARG (0.50) | FFAR1 | |
| Englitazone SCHEMBL20125577 | 0.79 | PPARG (0.50) | FFAR1 | |
| SCHEMBL10685552 | 0.78 | TSHR (0.34) | DDB1CRBNFFAR1TSHR | |
| Englitazone SCHEMBL22607925 | 0.78 | PPARG (0.49) | FFAR1 | |
| Englitazone SCHEMBL8522765 | 0.78 | PPARG (0.49) | FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207605-B1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4703052-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-10-27 | — | — | US | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |