Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.50 |
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10685155 | 0.84 | S1PR1 (0.40) | CYP26A1CYP19A1DDB1CRBNHTR1A | |
| SCHEMBL10366186 | 0.82 | HTR1A (0.36) | DDB1CRBNHTR1ASIGMAR1 | |
| SCHEMBL10685552 | 0.81 | TSHR (0.34) | DDB1CRBN | |
| SCHEMBL10688765 | 0.80 | MTNR1A (0.41) | — | |
| SCHEMBL10691392 | 0.80 | CYP26A1 (0.56) | CYP26A1CYP24A1CYP19A1DDB1CRBN | |
| SCHEMBL10681257 | 0.78 | MTNR1A (0.43) | SIGMAR1 | |
| SCHEMBL10684731 | 0.73 | TSHR (0.36) | DDB1CRBN | |
| SCHEMBL8158688 | 0.73 | CYP26A1 (0.86) | CYP26A1CYP24A1CYP19A1HTR1ASIGMAR1 | |
| SCHEMBL10686411 | 0.71 | CYP26A1 (0.61) | CYP26A1CYP24A1CYP19A1DDB1CRBN | |
| SCHEMBL13846705 | 0.71 | UGT2B7 (0.46) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738972-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1988-04-19 | — | — | US | disclosed |