Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7499608 | 0.75 | KDR (0.60) | DAOPDGFRBFGFR1KDRKDM4E | |
| SCHEMBL10691644 | 0.71 | DAO (0.50) | DAOPDGFRBFGFR1KDR | |
| SCHEMBL7502200 | 0.71 | KDR (0.40) | DAOPDGFRBFGFR1KDRTSHR | |
| SCHEMBL10692085 | 0.71 | DAO (0.52) | DAOPDGFRBFGFR1KDRKDM4E | |
| SCHEMBL7084680 | 0.71 | KDR (0.68) | PDGFRBFGFR1KDRKDM4ENPC1 | |
| Water SCHEMBL10691885 | 0.71 | KDM4E (0.42) | PDGFRBFGFR1KDRTSHRKDM4E | |
| SCHEMBL9700418 | 0.69 | CYP2A6 (0.34) | KDM4E | |
| SCHEMBL7503986 | 0.69 | IDH1 (0.43) | PDGFRBFGFR1KDRTSHRKDM4E | |
| SCHEMBL10686471 | 0.69 | KDR (0.37) | DAOPDGFRBFGFR1KDRTSHR | |
| SCHEMBL10690924 | 0.68 | NPBWR1 (0.40) | PDGFRBFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177924-B1 | (TETRAZOLYL)THIENOPYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-21 | — | — | EP | claimed |
| US-4593099-A | (Tetrazolyl) thienopyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-03 | — | — | US | claimed |
| EP-0177924-A1 | (Tetrazolyl)Thienopyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | claimed |
| EP-0177924-B1 | (TETRAZOLYL)THIENOPYRIDINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-21 | — | — | EP | disclosed |
| US-4593099-A | (Tetrazolyl) thienopyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0177924-A1 | (Tetrazolyl)Thienopyridinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |