Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10373566 | 0.78 | CYP1A2 (0.40) | DRD2DRD4 | |
| SCHEMBL10373749 | 0.73 | GAA (0.52) | L3MBTL1GAAMAPTIDO1CDK2 | |
| SCHEMBL2506350 | 0.73 | MAPT (0.42) | L3MBTL1TDP1GAAMAPTIDO1 | |
| Hydrochloric Acid SCHEMBL11063449 | 0.69 | TDP1 (0.43) | L3MBTL1TDP1PPARA | |
| Hydrochloric Acid SCHEMBL11069551 | 0.69 | TDP1 (0.43) | L3MBTL1TDP1PPARA | |
| Hydrochloric Acid SCHEMBL11063453 | 0.69 | TDP1 (0.43) | L3MBTL1TDP1PPARA | |
| SCHEMBL2364518 | 0.68 | GABRA1 (0.54) | CCNB2CDK1CCNB1CCNB3CCKAR | |
| SCHEMBL6157468 | 0.66 | MEN1 (0.45) | GAAMAPTCCNB2CDK1CCNB1 | |
| SCHEMBL6159010 | 0.66 | MEN1 (0.45) | GAAMAPTCCNB2CDK1CCNB1 | |
| SCHEMBL7572055 | 0.65 | GPR3 (0.35) | L3MBTL1TDP1GPR3LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0076017-B1 | PHENYL SUBSTITUTED PYRIDO(1,4)BENZODIAZEPINES AND INTERMEDIATES THEREFOR | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-16 | — | — | EP | claimed |
| EP-0076017-A2 | Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor | A.H. ROBINS COMPANY, INCORPORATED (US) | 1983-04-06 | — | — | EP | claimed |
| EP-0076017-B1 | PHENYL SUBSTITUTED PYRIDO(1,4)BENZODIAZEPINES AND INTERMEDIATES THEREFOR | A.H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-16 | — | — | EP | disclosed |
| EP-0107261-B1 | (2-((NITROPYRIDINYL)AMINO)PHENYL)ARYLMETHANONES AND SALTS, THEIR USE IN MEDICINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE PREPARATION OF (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONES AND PYRIDO(1,4)BENZODIAZEPINES | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-09-21 | — | — | EP | disclosed |
| US-4698430-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1987-10-06 | — | — | US | disclosed |
| US-4668675-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-05-26 | — | — | US | disclosed |
| US-4628100-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-12-09 | — | — | US | disclosed |
| US-4560510-A | CONDENSATION OF AN AMINOCHLOROPYRIDINE WITH A ARYL(AMINOPHENYL)METHANONE WITH A BASE) | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-24 | — | — | US | disclosed |
| US-4558132-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-10 | — | — | US | disclosed |
| US-4556667-A | (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0157656-A2 | Process and intermediates for the preparation of aryl substituded pyrido [1,4] benzodiazepines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-10-09 | — | — | EP | disclosed |
| US-4518603-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INC. (US) | 1985-05-21 | — | — | US | disclosed |
| US-4495183-A | ANTIULCER AGENTS- GASTROLINTESTINAL DISORDERS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-01-22 | — | — | US | disclosed |
| US-4480100-A | CHEMICAL INTERMEDIATES FOR ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INC. (US) | 1984-10-30 | — | — | US | disclosed |
| US-4447361-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0107261-A2 | (2-((Nitropyridinyl)amino)phenyl)arylmethanones and salts, their use in medicine, pharmaceutical compositions containing them and their use in the preparation of (2-((aminopyridinyl)amino)phenyl)arylmethanones and pyrido(1,4)benzodiazepines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-05-02 | — | — | EP | disclosed |
| EP-0099614-A2 | Nitro, amino and aroylamino-N-phenylpyridinamines and their use in a process for preparing pyrido(1,4)benzodiazapines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-02-01 | — | — | EP | disclosed |
| EP-0076017-A2 | Phenyl substituted pyrido(1,4)benzodiazepines and intermediates therefor | A.H. ROBINS COMPANY, INCORPORATED (US) | 1983-04-06 | — | — | EP | disclosed |