Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10763691 | 0.95 | OPRM1 (0.43) | OPRM1OPRK1CHRNA7 | |
| SCHEMBL10538680 | 0.93 | OPRM1 (0.39) | OPRM1OPRK1CHRNA7 | |
| SCHEMBL10375490 | 0.89 | HRH3 (0.43) | OPRM1OPRK1 | |
| SCHEMBL10740465 | 0.80 | OPRM1 (0.42) | OPRM1OPRK1CHRNA7 | |
| Hydrochloric Acid SCHEMBL9688043 | 0.79 | OPRM1 (0.41) | OPRM1OPRK1CHRNA7 | |
| SCHEMBL27696263 | 0.76 | GAA (0.47) | OPRM1OPRK1 | |
| SCHEMBL27677696 | 0.76 | OPRM1 (0.39) | OPRM1OPRK1CHRNA7 | |
| SCHEMBL10764392 | 0.75 | OPRM1 (0.43) | OPRM1OPRK1CHRNA7 | |
| SCHEMBL10763462 | 0.75 | OPRM1 (0.43) | OPRM1OPRK1CHRNA7 | |
| SCHEMBL13660513 | 0.75 | CHRNB2 (0.56) | OPRM1OPRK1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237169-B1 | 5-SUBSTITUTED OCTAHYDROINDOLIZINE ANALGESICS COMPOUNDS AND 7-KETO INTERMEDIATES | McNeilab, Inc. (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0237169-A1 | 5-Substituted octahydroindolizine analgesics compounds and 7-keto intermediates | McNeilab, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4689329-A | 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates | MCNEILAB, INC. (US) | 1987-08-25 | — | — | US | disclosed |