Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.55 |
| ▸ | KDM4B | O94953 | 1/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.55 |
| ▸ | WNT3A | P56704 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5419968 | 0.89 | KDM4E (0.52) | KDM4EALOX15ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2825544 | 0.87 | MAPT (0.64) | KDM4EALOX15ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL18997299 | 0.87 | ALDH1A1 (0.68) | KDM4EALOX15ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2826777 | 0.83 | NPSR1 (0.66) | KDM4EALOX15ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2829180 | 0.83 | MAPT (0.60) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL2827972 | 0.83 | MAPT (0.59) | ALOX15ALDH1A1SMN1; SMN2LMNAHTT | |
| SCHEMBL18997297 | 0.82 | KDM4E (0.62) | KDM4EALOX15ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2831060 | 0.81 | TRPA1 (0.58) | KDM4EALOX15ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2827630 | 0.81 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2LMNAHTTKMT2A | |
| SCHEMBL2830357 | 0.81 | TRPA1 (0.58) | KDM4EALOX15ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948616-B1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | ORGANON NV (NL) | 2011-01-26 | — | — | EP | claimed |
| EP-1948616-A1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | N.V. Organon (NL) | 2008-07-30 | — | — | EP | claimed |
| WO-2007054480-A1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | N.V. ORGANON (NL) | 2007-05-18 | — | — | WO | claimed |
| EP-1948616-B1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | ORGANON NV (NL) | 2011-01-26 | — | — | EP | disclosed |
| US-7482469-B2 | 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives | N.V. ORGANON (NL) | 2009-01-27 | — | — | US | disclosed |
| EP-1948616-A1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | N.V. Organon (NL) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054480-A1 | 2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR | N.V. ORGANON (NL) | 2007-05-18 | — | — | WO | disclosed |
| US-20070112034-A1 | 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives | AKZO NOBEL N.V. (NL) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112034-A1 | 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives | TRPV1, TRPV3, TRPV2 | KDM4E 4243/4885ALOX15 1176/4885ALDH1A1 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.