Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10376481 | 0.87 | ALOX15 (0.48) | MAOAALOX15MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL10378406 | 0.74 | ALOX15 (0.39) | MAOAMAOBALOX15DRD3 | |
| SCHEMBL10378104 | 0.71 | MAOA (0.38) | MAOAALOX15MAPTMAPK1KDM4E | |
| SCHEMBL10378389 | 0.69 | ALDH1A1 (0.38) | MAOAALOX15MAPTMAPK1TDP1 | |
| SCHEMBL22541416 | 0.65 | MAOA (0.59) | MAOAMAOBCDC25BTP53CYP3A4 | |
| SCHEMBL29350676 | 0.65 | MAOA (1.00) | MAOAMAOBALOX15CDC25BTP53 | |
| SCHEMBL421291 | 0.65 | MAOA (1.00) | MAOAMAOBALOX15CDC25BTP53 | |
| SCHEMBL19013209 | 0.63 | MAOA (0.87) | MAOAMAOBCDC25BTP53CYP3A4 | |
| SCHEMBL6926901 | 0.63 | MAOA (0.95) | MAOAMAOBALOX15CDC25BTP53 | |
| SCHEMBL23154411 | 0.63 | MAOA (0.67) | MAOAMAOBALOX15CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161102-B1 | ISOQUINOLINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1990-02-21 | — | — | EP | disclosed |