Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DNTT | P04053 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10378691 | 1.00 | SIGMAR1 (0.35) | SIGMAR1TMEM97CA1CA2CYP11B1 | |
| SCHEMBL10377563 | 0.85 | ALDH1A1 (0.40) | ALDH1A1MAPTKMT2ALMNAL3MBTL1 | |
| SCHEMBL10377561 | 0.85 | ALDH1A1 (0.40) | ALDH1A1MAPTKMT2ALMNAL3MBTL1 | |
| SCHEMBL10379184 | 0.84 | LMNA (0.46) | ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL10377661 | 0.84 | MAPT (0.46) | CYP11B1CYP11B2ALDH1A1MAPTKMT2A | |
| SCHEMBL10378505 | 0.84 | LMNA (0.46) | ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL10377357 | 0.84 | CYP1A2 (0.46) | KMT2AL3MBTL1 | |
| SCHEMBL10377359 | 0.84 | CYP1A2 (0.46) | KMT2AL3MBTL1 | |
| SCHEMBL10377663 | 0.83 | RECQL (0.43) | ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL10377662 | 0.83 | RECQL (0.43) | ALDH1A1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0168037-B1 | 1-6-NAPHTHYRIDIN-2(1H)-ONES USEFUL AS CARDIOTONICS | STERLING DRUG INC. (US) | 1990-02-07 | — | — | EP | disclosed |
| EP-0168037-A2 | 1-6-Naphthyridin-2(1H)-ones useful as cardiotonics | STERLING DRUG INC. (US) | 1986-01-15 | — | — | EP | disclosed |
| US-4560691-A | 5-(Phenyl)-1,6-naphthyridin-2(1H)-ones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1985-12-24 | — | — | US | disclosed |