SCHEMBL1038487

SCHEMBL1038487

CNCc1cccc(-c2cccnc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 6/20 1.00
EPHX2 P34913 1/20 1.00
BACE1 P56817 1/20 0.58
CYP2D6 P10635 7/20 0.53
CYP2C19 P33261 6/20 0.53
CYP2A6 P11509 4/20 0.53
CYP2C9 P11712 2/20 0.53
CYP1A2 P05177 6/20 0.50
CYP3A4 P08684 5/20 0.50
ALDH1A1 P00352 4/20 0.50
MEN1 O00255 2/20 0.50
NOS3 P29474 1/20 0.50
NOS1 P29475 1/20 0.50
PSIP1 O75475 1/20 0.50
AXL P30530 1/20 0.50
MKNK1 Q9BUB5 1/20 0.50
MKNK2 Q9HBH9 1/20 0.50
HPGD P15428 3/20 0.48
HSD17B10 Q99714 3/20 0.48
KDM4E B2RXH2 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL250253 0.85 PRMT6 (0.73) PRMT6EPHX2BACE1CYP2D6CYP2C19
SCHEMBL14676172 0.83 PRMT6 (1.00) PRMT6EPHX2CYP3A4NOS3NOS1
SCHEMBL13456617 0.83 PRMT6 (0.71) PRMT6EPHX2CYP2D6CYP2C19CYP2A6
SCHEMBL25584040 0.83 PRMT6 (0.70) PRMT6EPHX2BACE1CYP2D6CYP2C19
SCHEMBL2759632 0.81 EPHX2 (0.68) PRMT6EPHX2BACE1CYP2D6CYP2C19
SCHEMBL13778320 0.81 PRMT6 (0.68) PRMT6EPHX2BACE1CYP2A6CYP3A4
SCHEMBL46656 0.80
SCHEMBL5990304 0.80 PRMT6 (0.66) PRMT6EPHX2BACE1CYP2D6CYP2C19
SCHEMBL3724194 0.80 PRMT6 (0.66) PRMT6EPHX2BACE1CYP2D6CYP2C19
SCHEMBL22501576 0.78 EPHX2 (0.64) PRMT6EPHX2BACE1CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12018004-B2 Carbamate compounds and methods of making and using same H. LUNDBECK A/S (DK) 2024-06-25 US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 US disclosed
US-20220402883-A1 COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION ARRAKIS THERAPEUTICS, INC. 2022-12-22 US disclosed
US-11530189-B2 Carbamate compounds and methods of making and using same H. LUNDBECKA/S (DK) 2022-12-20 US disclosed
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES ARRAKIS THERAPEUTICS, INC. 2022-09-08 US disclosed
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME LUNDBECK LA JOLLA RESEARCH CENTER, INC. 2021-06-24 US disclosed
US-11021453-B2 Carbamate compounds and methods of making and using same LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) 2021-06-01 US disclosed
US-20200270223-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2020-08-27 US disclosed
EP-3698782-A1 CARBAMATE COMPOUNDS FOR USE IN THERAPY Lundbeck La Jolla Research Center, Inc. (US) 2020-08-26 EP disclosed
EP-2800565-B1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME LUNDBECK LA JOLLA RESEARCH CENTER INC (US) 2020-03-25 EP disclosed
US-9133148-B2 Carbamate compounds and of making and using same THE SCRIPPS RESEARCH INSTITUTE (US) 2015-09-15 US disclosed
WO-2015127559-A1 ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY VAL-CHUM, LIMITED PARTNERSHIP (CA) 2015-09-03 WO disclosed
WO-2015127559-A1 ABHD6 ANTAGONISTS FOR PROMOTING BROWNING OF WHITE ADIPOSE TISSUE AND BROWN ADIPOSE TISSUE FUNCTIONALITY VAL-CHUM, LIMITED PARTNERSHIP (CA) 2015-09-03 WO disclosed
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2015-05-28 US disclosed
US-20150080364-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME ABIDE THERAPEUTICS, INC. (US) 2015-03-19 US disclosed
CN-104379578-A Carbamate compounds and of making and using same ABIDE THERAPEUTICS 2015-02-25 CN disclosed
US-8586748-B2 2-sulfonylamino-4-heteroaryl butyramide antagonists of CCR10 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-11-19 US disclosed
US-20110275800-A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-11-10 US disclosed
EP-2276731-A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 Boehringer Ingelheim International GmbH (DE) 2011-01-26 EP disclosed
WO-2009126675-A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-10-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11530189-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 PRMT6 4/4885EPHX2 462/4885BACE1 1885/4885
US-11021453-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 PRMT6 4/4885EPHX2 460/4885BACE1 1978/4885
US-20220281860-A1 COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES NSUN3, NSUN2, POLRMT PRMT6 603/4885EPHX2 3332/4885BACE1 2717/4885
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, RABL6 PRMT6 4/4885EPHX2 462/4885BACE1 1885/4885
US-20200270223-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, NCEH1 PRMT6 8/4885EPHX2 500/4885BACE1 4017/4885
US-20220402883-A1 COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION NSUN3, NSUN2, METTL16 PRMT6 459/4885EPHX2 3780/4885BACE1 3933/4885
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, RABL6 PRMT6 4/4885EPHX2 462/4885BACE1 1885/4885
US-20150148330-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME ABHD6, ABHD16A, PRMT6 PRMT6 3/4885EPHX2 853/4885BACE1 4075/4885
US-12018004-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 PRMT6 4/4885EPHX2 462/4885BACE1 1885/4885
US-20150080364-A1 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME CPS1, FABP4, VHL PRMT6 118/4885EPHX2 2815/4885BACE1 3416/4885
US-20110275800-A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10 CCR10, CCR1, CCR4 PRMT6 1419/4885EPHX2 482/4885BACE1 4200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.