Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27744090 | 0.85 | ALDH1A1 (0.54) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL28029397 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL474709 | 0.81 | KMT2A (0.70) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL6209273 | 0.80 | LMNA (0.54) | ALDH1A1HSD17B10RAB9ATP53LMNA | |
| SCHEMBL16738057 | 0.79 | POLB (0.61) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL11682733 | 0.78 | RAB9A (0.54) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL7023178 | 0.78 | ALDH1A1 (0.61) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL31022695 | 0.78 | MEN1 (0.62) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL758991 | 0.78 | MEN1 (0.62) | ALDH1A1HSD17B10CYP1A2RAB9ATP53 | |
| SCHEMBL11129363 | 0.77 | PKM (0.61) | ALDH1A1HSD17B10CYP1A2RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963570-A | ANTIDEPRESSANTS; CENTRAL NERVOUS SYSTEM | LABORATOIRE L. LAFON (FR) | 1990-10-16 | — | — | US | disclosed |
| US-4933442-A | 1-(acetylaminophenyl)-2-aminopropanone derivatives and central nervous system antidepressant compositions | LABORATOIRE L. LAFON (FR) | 1990-06-12 | — | — | US | disclosed |
| US-4877812-A | 1-(acetylaminophenyl)-2-aminopropanone derivatives and antidepressant compositions thereof | LABORATOIRE L. LAFON (FR) | 1989-10-31 | — | — | US | disclosed |