Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.78 |
| ▸ | MAPT | P10636 | 9/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.71 |
| ▸ | MEN1 | O00255 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | STAT3 | P40763 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | RECQL | P46063 | 6/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31253342 | 1.00 | MAOA (0.78) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2999253 | 0.95 | MAOA (0.71) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| 1-Hydroxyanthraquinone SCHEMBL145303 | 0.91 | MAOA (0.86) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| 1-Hydroxyanthraquinone SCHEMBL30912125 | 0.91 | MAOA (0.86) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| Anthrarufin SCHEMBL25355428 | 0.91 | MAOA (0.86) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| Anthrarufin SCHEMBL11422341 | 0.89 | MAPT (0.83) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| 1-Hydroxyanthraquinone SCHEMBL1893347 | 0.89 | MAOA (0.83) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| Naphthazalin SCHEMBL8047605 | 0.89 | MAPT (0.62) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| Anthrarufin SCHEMBL187843 | 0.88 | MAOA (1.00) | MAOAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL875843 | 0.88 | MAPT (0.86) | MAOAMAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958288-B1 | PHOTOCHROMIC NAPHTOPYRANE COLORANTS, METHOD FOR THE PRODUCTION AND USE THEREOF, PHOTOCHROMIC OBJECT | RODENSTOCK GMBH (DE) | 2004-03-03 | — | — | EP | claimed |
| US-6146554-A | FOR PHOTOCHROMIC PLASTIC LENSES IN MASS-DYEING PROCESSES | OPTISCHE WERKE G. RODENSTOCK (DE) | 2000-11-14 | — | — | US | claimed |
| EP-0958288-A1 | PHOTOCHROMIC NAPHTOPYRANE COLORANTS, METHOD FOR THE PRODUCTION AND USE THEREOF, PHOTOCHROMIC OBJECT | Optische Werke G. Rodenstock (DE) | 1999-11-24 | — | — | EP | claimed |
| WO-1999015518-A1 | PHOTOCHROMIC NAPHTOPYRANE COLORANTS, METHOD FOR THE PRODUCTION AND USE THEREOF, PHOTOCHROMIC OBJECT | OPTISCHE WERKE G. RODENSTOCK (DE) | 1999-04-01 | — | — | WO | claimed |
| US-5492803-A | Hydrazide redox-dye-releasing compounds for photothermographic elements | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-02-20 | — | — | US | claimed |
| US-4605761-A | Process using achiral co-catalyst promoter for chiral phase transfer alkylation process for an enantiomer of a substituted fluorenyloxyacetic acid | MERCK & CO., INC. (US) | 1986-08-12 | — | — | US | claimed |
| EP-4438693-A2 | HETEROCYCLIC SPIRO COMPOUNDS | Merck Patent GmbH (DE) | 2024-10-02 | — | — | EP | disclosed |
| EP-3708634-B1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2024-08-14 | — | — | EP | disclosed |
| WO-2023242454-A1 | HYBRID MATERIAL FOR DETECTING ACID AND BASE VAPOURS | UNIVERSIDAD DE CASTILLA LA MANCHA (ES) | 2023-12-21 | — | — | WO | disclosed |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | MERCK PATENT GMBH (DE) | 2023-04-27 | — | — | US | disclosed |
| US-11612598-B2 | Compounds and methods for the treatment of cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-03-28 | — | — | US | disclosed |
| US-11545634-B2 | Heterocyclic spiro compounds | MERCK PATENT GMBH (DE) | 2023-01-03 | — | — | US | disclosed |
| US-11512204-B2 | Squarylium dye and composition containing same | TOYO INK SC HOLDINGS CO., LTD. (JP) | 2022-11-29 | — | — | US | disclosed |
| US-4137331-A | ANTIARRYTHMIA AGENTS | SANDOZ LTD. (CH) | 1979-01-30 | — | — | US | disclosed |
| US-4134994-A | CATALYSTS FOR POLYURETHANE SYNTHESIS, EXHIBIT DELAYED ACTION | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4115634-A | URETHANE BY POLYMERIZING POLYISOCYANATE AND COMPOUND WITH ACTIVE HYDROGEN, ORGANOMETALLIC CATALYST | AIR PRODUCTS & CHEMICALS, INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-4086213-A | FOR POLYURETHANE SYNTHESIS | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4009150-A | CHELATE COMPOUNDS, REDUCING AGENTS, INITIATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-02-22 | — | — | US | disclosed |
| US-3987067-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3959319-A | FREE FLOWING CRYSTALS | THE UPJOHN COMPANY (US) | 1976-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11545634-B2 | Heterocyclic spiro compounds | NES, KCNC1, HCN4 | MAOA 3085/4885MAPT 3089/4885KMT2A 3328/4885 |
| US-11612598-B2 | Compounds and methods for the treatment of cancer | CASP3, BAX, CASP6 | MAOA 2023/4885MAPT 3799/4885KMT2A 3132/4885 |
| US-20230126850-A1 | HETEROCYCLIC SPIRO COMPOUNDS | NES, KCNC1, HCN4 | MAOA 3085/4885MAPT 3089/4885KMT2A 3328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.