Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10401560 | 0.99 | NPC1 (0.45) | NPC1GFERTP53LMNAPOLB | |
| SCHEMBL10401512 | 0.87 | GFER (0.58) | NPC1GFERLMNAKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10402024 | 0.86 | GFER (0.57) | NPC1GFERLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10401976 | 0.81 | L3MBTL1 (0.59) | NPC1GFERTP53LMNAPOLB | |
| SCHEMBL10401429 | 0.80 | KMT2A (0.56) | GFERLMNAPOLBKMT2A | |
| SCHEMBL10401428 | 0.79 | NPC1 (0.62) | NPC1LMNA | |
| SCHEMBL10401826 | 0.77 | DRD2 (0.62) | TP53LMNAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL10401922 | 0.76 | MAPT (0.51) | NPC1GFERTP53LMNAPOLB | |
| SCHEMBL10401523 | 0.75 | ALDH1A1 (0.50) | NPC1GFERTP53LMNASMN1; SMN2 | |
| SCHEMBL10401849 | 0.75 | CHRM4 (0.54) | LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4960776-A | ANTIALLERGENS | A. H. ROBINS COMPANY, INC. (US) | 1990-10-02 | — | — | US | claimed |
| EP-0277725-A2 | 4-Aryl-N-[2-(dialkylamino and heterocyclicamino) alkyl]-1-piperazinecarboxamides and their use as anti allergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-08-10 | — | — | EP | claimed |