Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11607315 | 0.81 | MEN1 (0.41) | LMNASMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL10755843 | 0.77 | KMT2A (0.40) | CACNA2D1CACNA1BCACNB1CACNA1CLMNA | |
| SCHEMBL8600205 | 0.74 | POLB (0.40) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL10754281 | 0.74 | BRD4 (0.43) | NPSR1ALDH1A1SMN1; SMN2KMT2ACYP2D6 | |
| SCHEMBL10543158 | 0.74 | POLB (0.40) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL10702187 | 0.74 | LMNA (0.35) | LMNAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL10751872 | 0.73 | MEN1 (0.52) | CACNA2D1CACNA1BCACNB1CACNA1CLMNA | |
| SCHEMBL10700196 | 0.72 | TSHR (0.36) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8622094 | 0.72 | MEN1 (0.38) | CACNA2D1CACNA1BCACNB1CACNA1CLMNA | |
| SCHEMBL8626924 | 0.69 | CACNA2D1 (0.39) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4940702-A | Cephem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-07-10 | — | — | US | disclosed |
| EP-0211656-A2 | Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-02-25 | — | — | EP | disclosed |