Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748579 | 0.89 | ALOX5 (0.51) | ALOX5MGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL21682970 | 0.85 | MGLL (0.53) | ALOX5MGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL9831474 | 0.82 | ALOX5 (0.33) | ALOX5MEN1KMT2A | |
| SCHEMBL10408075 | 0.81 | HTR3E (0.54) | ALOX5ALDH1A1LMNATP53 | |
| SCHEMBL10408119 | 0.79 | ALOX5 (0.49) | ALOX5MGLLMEN1KMT2AALDH1A1 | |
| SCHEMBL1459854 | 0.79 | L3MBTL1 (0.54) | ALOX5MGLLALDH1A1L3MBTL1LMNA | |
| SCHEMBL10407318 | 0.78 | AKR1C3 (0.41) | MGLLMEN1KMT2AL3MBTL1 | |
| SCHEMBL27866033 | 0.78 | EED (0.54) | MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL1953072 | 0.77 | MEN1 (0.45) | ALOX5MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9829836 | 0.77 | MAOB (0.36) | MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |