Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650233 | 0.72 | LIPE (0.40) | ALDH1A1KDM4ENPSR1SMN1; SMN2LIPE | |
| SCHEMBL27524849 | 0.72 | PGR (0.47) | ALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7159347 | 0.72 | PGR (0.47) | ALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL28799995 | 0.71 | POLB (0.39) | ALDH1A1LIPEPOLBTSHR | |
| SCHEMBL27911321 | 0.70 | CA12 (0.36) | ATMALDH1A1KDM4ETAS1R3TAS1R1 | |
| SCHEMBL20557723 | 0.70 | LIPE (0.40) | ALDH1A1KDM4ENPSR1SMN1; SMN2LIPE | |
| SCHEMBL762423 | 0.67 | ALDH1A1 (0.50) | ALDH1A1KDM4ENPSR1SMN1; SMN2LIPE | |
| SCHEMBL55668 | 0.67 | EPOR (0.52) | ATM | |
| SCHEMBL56847 | 0.67 | EPOR (0.52) | ATM | |
| SCHEMBL55669 | 0.67 | EPOR (0.52) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977277-A | INTERMEDIATES FOR RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-12-11 | — | — | US | disclosed |
| US-4837204-A | RENIN INHIBITORS; HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0230266-A2 | Functionalized peptidyl aminodiols and -triols | ABBOTT LABORATORIES (US) | 1987-07-29 | — | — | EP | disclosed |