Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650430 | 0.89 | POLB (0.39) | LIPEPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL7279887 | 0.89 | POLB (0.39) | LIPEPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL7307868 | 0.80 | RAB9A (0.36) | KMT2ASMN1; SMN2NPSR1MEN1RAB9A | |
| SCHEMBL7307862 | 0.80 | RAB9A (0.36) | KMT2ASMN1; SMN2NPSR1MEN1RAB9A | |
| SCHEMBL761922 | 0.76 | ALOX15 (0.45) | LIPEPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL20484557 | 0.74 | HTT (0.49) | POLBALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL20557723 | 0.72 | LIPE (0.40) | LIPEPOLBALDH1A1KDM4EKMT2A | |
| SCHEMBL10407604 | 0.72 | ATM (0.39) | LIPEPOLBALDH1A1LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL4621439 | 0.71 | HDAC6 (0.46) | POLBALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1028262 | 0.69 | CYP1A2 (0.57) | POLBALDH1A1LMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423167-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING QUINALDOYL-AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS | Elan Pharmaceuticals, Inc. (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003020370-A1 | METHOD FOR TREATING ALZHEIMER'S DISEASE USING QUINALDOYL-AMINE DERIVATIVES OF OXO- AND HYDROXY-SUBSTITUTED HYDROCARBONS | ELAN PHARMACEUTICALS, INC. (US) | 2003-03-13 | — | — | WO | disclosed |
| CN-1090612-C | Amine derivatives of oxo-and hydroxy-substituted hydrocarbons | NARHEX LTD (HK) | 2002-09-11 | — | — | CN | disclosed |
| CN-1100090-A | amine derivatives of oxo-and hydroxy-substituted hydrocarbons | NARHEX LTD (HK) | 1995-03-15 | — | — | CN | disclosed |