Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412510 | 0.94 | DRD2 (0.45) | KCNH2HTR6DRD2DRD4DRD3 | |
| SCHEMBL10413252 | 0.93 | KCNH2 (0.52) | KCNH2HTR6HTR1ASLC6A4HTR7 | |
| SCHEMBL10414161 | 0.90 | DRD2 (0.47) | KCNH2DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10413763 | 0.87 | HTR1A (0.49) | KCNH2HTR6HTR1ASLC6A4HTR7 | |
| SCHEMBL10414268 | 0.86 | DRD4 (0.45) | KCNH2HTR6DRD2DRD4DRD3 | |
| SCHEMBL11351695 | 0.85 | HTR1A (0.60) | SIGMAR1HTR1A | |
| SCHEMBL10652767 | 0.84 | DRD2 (0.48) | DRD2DRD4DRD3SIGMAR1MEN1 | |
| SCHEMBL10413001 | 0.84 | MAOB (0.52) | DRD2DRD4DRD3HTR1A | |
| SCHEMBL9828281 | 0.83 | HTR1A (0.53) | KCNH2HTR6HTR1ASLC6A4HTR7 | |
| SCHEMBL10414152 | 0.82 | HTR1A (0.52) | KCNH2HTR1ASLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |