Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.32 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10414814 | 0.91 | CYP3A4 (0.31) | XIAPALDH1A1CYP3A4MAPTHSD17B10 | |
| SCHEMBL10412840 | 0.90 | HSD17B10 (0.40) | NR1I2SLC22A6SLC22A8ALDH1A1CYP3A4 | |
| SCHEMBL10547432 | 0.85 | KMT2A (0.42) | ALDH1A1KMT2AMAPK1 | |
| SCHEMBL10413872 | 0.84 | MAPK1 (0.38) | SLC22A8ALDH1A1CYP3A4POLBCYP2C19 | |
| SCHEMBL10413404 | 0.82 | MAPT (0.39) | SLC22A6SLC22A8SLC22A11MAPTHSD17B10 | |
| SCHEMBL10414816 | 0.79 | KDM4E (0.33) | HSD17B10TDP1KDM4EKMT2A | |
| SCHEMBL10414276 | 0.79 | TYMP (0.30) | — | |
| SCHEMBL10413424 | 0.78 | KDM5A (0.30) | NR1I2PGR | |
| SCHEMBL10551840 | 0.76 | KMT2A (0.42) | ALDH1A1KMT2AMAPK1 | |
| SCHEMBL10414811 | 0.76 | MAPT (0.31) | SLC22A6SLC22A8SLC22A11MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4912214-A | Containing azelidin-2-one ring | HOFFMAN-LA ROCHE INC. (US) | 1990-03-27 | — | — | US | disclosed |