Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412980 | 0.94 | HTR1D (0.47) | DRD2DRD4DRD3SIGMAR1HTR1D | |
| SCHEMBL10412992 | 0.89 | SLC18A3 (0.47) | DRD2DRD4DRD3SIGMAR1HTR1D | |
| SCHEMBL10413746 | 0.89 | HTR1A (0.48) | DRD2DRD4DRD3SIGMAR1HTR1D | |
| SCHEMBL10650004 | 0.88 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1SLC18A3 | |
| SCHEMBL10414153 | 0.88 | DRD2 (0.43) | DRD2DRD4DRD3SIGMAR1HTR1D | |
| SCHEMBL10413339 | 0.86 | DRD2 (0.45) | DRD2DRD4DRD3SIGMAR1SLC18A3 | |
| SCHEMBL10414224 | 0.85 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10414180 | 0.84 | HTR1A (0.51) | DRD2DRD4DRD3SIGMAR1HTR1B | |
| SCHEMBL10413272 | 0.84 | HTR1A (0.51) | DRD2DRD4DRD3SIGMAR1HTR1B | |
| SCHEMBL10413753 | 0.84 | HTR1A (0.51) | DRD2DRD4DRD3SIGMAR1HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |