Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412977 | 0.94 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10650004 | 0.92 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10412992 | 0.91 | SLC18A3 (0.47) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10412980 | 0.89 | HTR1D (0.47) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10413746 | 0.89 | HTR1A (0.48) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10414224 | 0.88 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10414153 | 0.88 | DRD2 (0.43) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10412925 | 0.86 | DRD2 (0.41) | DRD2DRD4DRD3SIGMAR1BCHE | |
| SCHEMBL10414179 | 0.86 | HTR1A (0.51) | HTR7 | |
| SCHEMBL10650001 | 0.86 | DRD2 (0.49) | DRD2DRD4DRD3SIGMAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |