Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.46 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412924 | 0.85 | SLC18A3 (0.47) | SLC18A3SIGMAR1HTR7TACR1 | |
| SCHEMBL10413239 | 0.85 | SIGMAR1 (0.47) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL10413760 | 0.85 | SLC18A3 (0.48) | SLC18A3SIGMAR1MEN1TP53CYP1A2 | |
| SCHEMBL10413234 | 0.83 | HTR6 (0.49) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL11252927 | 0.82 | SIGMAR1 (0.54) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL9828847 | 0.81 | HTR1A (0.54) | — | |
| SCHEMBL10413001 | 0.81 | MAOB (0.52) | SLC18A3 | |
| SCHEMBL10413002 | 0.81 | HTR6 (0.45) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL11241323 | 0.80 | SIGMAR1 (0.51) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL30630333 | 0.79 | MTNR1A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |