Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10551027 | 0.87 | KDM4E (0.34) | HSD17B10GABRA5GABRB2L3MBTL1SMN1; SMN2 | |
| SCHEMBL10413872 | 0.82 | MAPK1 (0.38) | L3MBTL1SMN1; SMN2ALDH1A1TSHRLMNA | |
| SCHEMBL10414278 | 0.81 | POLB (0.38) | HSD17B10L3MBTL1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL10413424 | 0.81 | KDM5A (0.30) | — | |
| SCHEMBL10413422 | 0.81 | KDM5A (0.30) | — | |
| SCHEMBL10414816 | 0.81 | KDM4E (0.33) | HSD17B10KDM4ELMNATDP1 | |
| SCHEMBL10412892 | 0.80 | NR1I2 (0.45) | HSD17B10L3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL10413413 | 0.78 | ESR1 (0.40) | HSD17B10L3MBTL1ALDH1A1KDM4ETSHR | |
| SCHEMBL10414277 | 0.78 | — | — | |
| SCHEMBL10414303 | 0.77 | ALDH1A1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4912214-A | Containing azelidin-2-one ring | HOFFMAN-LA ROCHE INC. (US) | 1990-03-27 | — | — | US | disclosed |