Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 9/20 | 0.48 |
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | HTR1D | P28221 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412990 | 0.87 | HTR1A (0.55) | HTR1BHTR1AHTR1DMAPTMAPK1 | |
| SCHEMBL10412539 | 0.86 | HTR1A (0.51) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL10412507 | 0.86 | HTR1A (0.51) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL10413272 | 0.86 | HTR1A (0.51) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL10413753 | 0.86 | HTR1A (0.51) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL10414180 | 0.86 | HTR1A (0.51) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL10413237 | 0.86 | HTR1A (0.51) | HTR1BHTR1ADRD2DRD4DRD3 | |
| SCHEMBL10414153 | 0.85 | DRD2 (0.43) | HTR1BHTR1AHTR1DDRD2DRD4 | |
| SCHEMBL10413250 | 0.84 | DRD2 (0.45) | HTR1AHTR2ADRD2DRD4DRD3 | |
| SCHEMBL10412992 | 0.84 | SLC18A3 (0.47) | HTR1DDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916143-A | Hydroxyindole esters | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |