SCHEMBL10415604

SCHEMBL10415604

CC1(c2ccc(F)cc2)OC(=S)N(Nc2ccccc2)C1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39
CYP1A2 P05177 1/20 0.36
ALDH1A1 P00352 7/20 0.35
TSHR P16473 1/20 0.35
NR3C2 P08235 1/20 0.33
KCNN4 O15554 1/20 0.33
NPC1 O15118 1/20 0.33
POLB P06746 1/20 0.33
MAOB P27338 1/20 0.33
RAB9A P51151 1/20 0.33
TDP1 Q9NUW8 3/20 0.32
MPO P05164 1/20 0.32
XDH P47989 1/20 0.32
MAPT P10636 3/20 0.31
GAA P10253 2/20 0.31
HPGD P15428 2/20 0.31
ALOX12 P18054 1/20 0.31
CCR6 P51684 1/20 0.31
CACNA1B Q00975 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9374306 0.91 CYP1A2 (0.40) HCAR3HCAR2CYP1A2ALDH1A1TDP1
SCHEMBL9370810 0.91 CYP1A2 (0.40) HCAR3HCAR2CYP1A2ALDH1A1TDP1
SCHEMBL9375669 0.91 CYP1A2 (0.40) HCAR3HCAR2CYP1A2ALDH1A1TDP1
SCHEMBL13806763 0.89 HCAR2 (0.39) HCAR3HCAR2CYP1A2ALDH1A1TDP1
SCHEMBL13806769 0.86 HCAR2 (0.44) HCAR3HCAR2CYP1A2ALDH1A1NR3C2
SCHEMBL13806776 0.86 HSD11B1 (0.39) HCAR3HCAR2CYP1A2ALDH1A1NR3C2
SCHEMBL8908555 0.85 MMP2 (0.40) CYP1A2ALDH1A1NPC1MAPTHPGD
SCHEMBL9370365 0.85 PGR (0.38) HCAR2TSHRRAB9AMAPTHPGD
SCHEMBL9868603 0.83 HCAR2 (0.44) HCAR3HCAR2CYP1A2ALDH1A1NPC1
SCHEMBL9370299 0.82 MAPT (0.36) CYP1A2ALDH1A1MAPTHSD11B1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4957933-A Fungicidal oxazolidinones E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-09-18 US claimed
US-4957933-A Fungicidal oxazolidinones E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-09-18 US disclosed