SCHEMBL9374306

SCHEMBL9374306

C[C@]1(c2ccccc2)OC(=S)N(Nc2ccccc2)C1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.40
HCAR3 P49019 1/20 0.37
HCAR2 Q8TDS4 1/20 0.37
ALDH1A1 P00352 9/20 0.36
TDP1 Q9NUW8 4/20 0.36
MAPT P10636 7/20 0.35
GAA P10253 3/20 0.35
NPSR1 Q6W5P4 3/20 0.35
HTT P42858 2/20 0.35
HPGD P15428 2/20 0.35
ALOX12 P18054 2/20 0.35
CACNA1B Q00975 2/20 0.35
APBA1 Q02410 2/20 0.35
CCR6 P51684 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
DHODH Q02127 1/20 0.33
CASP6 P55212 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9375669 1.00 CYP1A2 (0.40) CYP1A2HCAR3HCAR2ALDH1A1TDP1
SCHEMBL9370810 1.00 CYP1A2 (0.40) CYP1A2HCAR3HCAR2ALDH1A1TDP1
SCHEMBL10415604 0.91 HCAR3 (0.39) CYP1A2HCAR3HCAR2ALDH1A1TDP1
SCHEMBL8908555 0.88 MMP2 (0.40) CYP1A2ALDH1A1MAPTHTTHPGD
SCHEMBL13806770 0.87 HCAR3 (0.44) CYP1A2HCAR3HCAR2ALDH1A1MAPT
SCHEMBL13806776 0.87 HSD11B1 (0.39) CYP1A2HCAR3HCAR2ALDH1A1MAPT
SCHEMBL13806769 0.87 HCAR2 (0.44) CYP1A2HCAR3HCAR2ALDH1A1HPGD
SCHEMBL13806765 0.87 ALDH1A1 (0.35) CYP1A2HCAR3HCAR2ALDH1A1TDP1
SCHEMBL13806763 0.87 HCAR2 (0.39) CYP1A2HCAR3HCAR2ALDH1A1TDP1
SCHEMBL9370299 0.85 MAPT (0.36) CYP1A2ALDH1A1MAPTL3MBTL1HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5356908-A Agriculture E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-10-18 US disclosed
EP-0393911-B1 Fungicidal oxazolidinones DU PONT (US) 1994-08-31 EP disclosed
US-5223523-A Agriculture E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-06-29 US disclosed
EP-0469061-A1 FUNGICIDAL OXAZOLIDINONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-02-05 EP disclosed
WO-1991015480-A1 FUNGICIDAL OXAZOLIDINONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-10-17 WO disclosed
WO-1990012791-A1 FUNGICIDAL OXAZOLIDINONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-11-01 WO disclosed
EP-0393911-A1 Fungicidal oxazolidinones E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-10-24 EP disclosed