Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28733754 | 0.83 | KIF11 (0.50) | RAB9ANPC1ABCB11HDAC6KDM1A | |
| SCHEMBL10417276 | 0.78 | ABCB11 (0.67) | LMNAMEN1KMT2ANPC1ABCB11 | |
| SCHEMBL27685289 | 0.75 | ABCB11 (0.49) | LMNAMEN1KMT2ANPC1ABCB11 | |
| SCHEMBL10417635 | 0.75 | KIF11 (0.60) | MEN1KMT2ANOTUMKDM1AALDH1A1 | |
| SCHEMBL10418651 | 0.75 | KIF11 (0.39) | ABCB11HDAC6PIM1ELOVL1KDM4E | |
| SCHEMBL20172469 | 0.73 | KMT2A (0.62) | LMNAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1505919 | 0.73 | ABCB11 (0.60) | LMNAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL15885350 | 0.73 | NAMPT (0.43) | KMT2ANAMPTALDH1A1SMN1; SMN2PIM1 | |
| SCHEMBL10417584 | 0.72 | ABCB11 (0.75) | LMNAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL10417591 | 0.72 | ABCB11 (0.71) | LMNAMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | claimed |
| EP-0178035-A1 | Anti-inflammatory 1,N-diarylpyrazol-3-amines, compositions containing them and processes for their preparation | FISONS plc (GB) | 1986-04-16 | — | — | EP | claimed |
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | disclosed |
| US-4810719-A | Anti-inflammator 1,n-diarylpyrazol-3-amines | FISONS PLC (GB) | 1989-03-07 | — | — | US | disclosed |
| EP-0178035-A1 | Anti-inflammatory 1,N-diarylpyrazol-3-amines, compositions containing them and processes for their preparation | FISONS plc (GB) | 1986-04-16 | — | — | EP | disclosed |