Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.60 |
| ▸ | PHGDH | O43175 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28733754 | 0.86 | KIF11 (0.50) | KIF11CTSCTSHRKDM1AEPHX2 | |
| SCHEMBL10417190 | 0.86 | ALDH1A1 (0.55) | NOTUMALDH1A1KMT2AMEN1AURKA | |
| SCHEMBL10418651 | 0.81 | KIF11 (0.39) | KIF11KDM4E | |
| SCHEMBL31013382 | 0.79 | KIF11 (0.47) | KIF11CTSCTSHRALDH1A1AURKA | |
| SCHEMBL9279109 | 0.79 | ALDH1A1 (0.45) | NOTUMALDH1A1KMT2AMEN1KDM1A | |
| SCHEMBL10417209 | 0.78 | ABCB11 (0.67) | NOTUMALDH1A1KMT2AMEN1POLB | |
| SCHEMBL10226426 | 0.77 | NOTUM (0.52) | NOTUMALDH1A1KMT2AMEN1KDM1A | |
| SCHEMBL27685302 | 0.76 | KDM1A (0.49) | KIF11ALDH1A1KMT2AMEN1AURKA | |
| SCHEMBL10417304 | 0.75 | LMNA (0.45) | NOTUMALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL20172492 | 0.72 | KIF11 (0.66) | KIF11CTSCTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | claimed |
| EP-0178035-A1 | Anti-inflammatory 1,N-diarylpyrazol-3-amines, compositions containing them and processes for their preparation | FISONS plc (GB) | 1986-04-16 | — | — | EP | claimed |
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | disclosed |
| EP-0178035-A1 | Anti-inflammatory 1,N-diarylpyrazol-3-amines, compositions containing them and processes for their preparation | FISONS plc (GB) | 1986-04-16 | — | — | EP | disclosed |