Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11068412 | 0.86 | MEN1 (0.54) | MAPTMAPK1HTTALDH1A1LMNA | |
| SCHEMBL908010 | 0.79 | GAA (0.46) | MAPTMAPK1ALDH1A1LMNATDP1 | |
| SCHEMBL11064115 | 0.76 | MEN1 (0.58) | MAPTMAPK1HTTALDH1A1LMNA | |
| SCHEMBL908494 | 0.76 | CA1 (0.56) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL11060055 | 0.76 | EGFR (0.53) | MAPTMAPK1HTTALDH1A1LMNA | |
| SCHEMBL11060811 | 0.76 | PRKCZ (0.56) | MEN1KMT2AATM | |
| SCHEMBL10374292 | 0.73 | MAPT (0.43) | MAPTNPEPPSMAPK1HTTALDH1A1 | |
| SCHEMBL11102158 | 0.72 | L3MBTL1 (0.69) | MEN1KMT2A | |
| SCHEMBL8637990 | 0.72 | PRKCZ (0.46) | MAPTMAPK1HTTALDH1A1LMNA | |
| SCHEMBL11104257 | 0.72 | EGFR (0.57) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178035-B1 | ANTI-INFLAMMATORY 1,N-DIARYLPYRAZOL-3-AMINES, COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | FISONS plc (GB) | 1990-01-03 | — | — | EP | disclosed |
| US-4810719-A | Anti-inflammator 1,n-diarylpyrazol-3-amines | FISONS PLC (GB) | 1989-03-07 | — | — | US | disclosed |
| CN-85103468-A | Prepare the method for new compound and new purposes thereof | — | 1986-09-10 | — | — | CN | disclosed |