Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 3/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 3/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10419940 | 1.00 | ACE (0.45) | ACEACE2ELANESTAT6DPP4 | |
| SCHEMBL10419941 | 0.90 | ELANE (0.47) | ACEACE2ELANESTAT6DPP4 | |
| SCHEMBL10419943 | 0.90 | ELANE (0.47) | ACEACE2ELANESTAT6DPP4 | |
| SCHEMBL28665808 | 0.76 | ITGB3 (0.49) | ACEACE2ELANESTAT6APLNR | |
| SCHEMBL7324427 | 0.76 | ACE (0.57) | ACEACE2DPP4DPP8DPP7 | |
| SCHEMBL13448495 | 0.76 | ITGB3 (0.49) | ACEACE2ELANESTAT6APLNR | |
| SCHEMBL13795060 | 0.76 | ITGB3 (0.49) | ACEACE2ELANESTAT6APLNR | |
| SCHEMBL10701507 | 0.76 | ELANE (0.41) | ELANEF2PRSS1 | |
| SCHEMBL30342385 | 0.76 | CAPN1 (0.45) | ACEELANESTAT6APLNRF2 | |
| SCHEMBL11196872 | 0.75 | OPRM1 (0.40) | ELANENTSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4950651-A | Leukemia; antitumer agents | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA R.T. (HU) | 1990-08-21 | — | — | US | disclosed |