Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | PI4KA | P42356 | 2/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11146247 | 0.83 | KDM4E (0.42) | XDHSRCEGFRKDM4EALDH1A1 | |
| SCHEMBL21731040 | 0.83 | SRC (0.38) | SRCCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL9381563 | 0.81 | ADORA2A (0.35) | SRCCHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10430710 | 0.80 | KDM5A (0.37) | AURKASRCEGFREGLN2KDM4E | |
| SCHEMBL9378832 | 0.79 | ALDH1A1 (0.36) | SRCEGFREGLN2KDM4EALDH1A1 | |
| SCHEMBL11151560 | 0.79 | KDM5A (0.40) | SRCEGFREGLN2KDM4EALDH1A1 | |
| SCHEMBL21731050 | 0.77 | ADORA2A (0.64) | KDM4EMAPTMAPK1ADORA2AADORA2B | |
| SCHEMBL9378347 | 0.76 | SRC (0.36) | SRCEGFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21731009 | 0.74 | ADORA2A (0.44) | ADORA2AADORA3ADORA2BADORA1MEN1 | |
| SCHEMBL21731151 | 0.74 | GABRA1 (0.41) | SRCCHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3611174-B1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | MEDSHINE DISCOVERY INC (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3611174-A1 | [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR | Medshine Discovery Inc. (CN) | 2020-02-19 | — | — | EP | disclosed |
| EP-0374914-A1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | G.D. Searle & Co. (US) | 1990-06-27 | — | — | EP | disclosed |
| US-4866063-A | Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines | G. D. SEARLE & CO. (US) | 1989-09-12 | — | — | US | disclosed |