Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | PI4KA | P42356 | 2/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31694571 | 0.84 | EGLN2 (0.46) | ADORA2AADORA1ADORA2BALDH1A1HSD17B10 | |
| SCHEMBL10430692 | 0.83 | XDH (0.42) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL21731050 | 0.82 | ADORA2A (0.64) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL21731040 | 0.82 | SRC (0.38) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL10430710 | 0.78 | KDM5A (0.37) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL21731056 | 0.78 | ADORA2A (0.51) | ADORA2AADORA1ADORA3ADORA2BMEN1 | |
| SCHEMBL11151560 | 0.77 | KDM5A (0.40) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL9381563 | 0.77 | ADORA2A (0.35) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL9378832 | 0.77 | ALDH1A1 (0.36) | KDM4EMAPTMAPK1ADORA2AADORA1 | |
| SCHEMBL21731093 | 0.77 | ADORA2A (0.67) | ADORA2AADORA1ADORA2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405780-A | 8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1983-09-20 | — | — | US | claimed |
| US-4405780-A | 8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1983-09-20 | — | — | US | disclosed |