Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | ABL2 | P42684 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378832 | 0.78 | ALDH1A1 (0.36) | SRCEGFRABL1EGLN1KDM4E | |
| SCHEMBL10430692 | 0.76 | XDH (0.42) | SRCEGFRABL1KDM4EALDH1A1 | |
| SCHEMBL11146247 | 0.74 | KDM4E (0.42) | SRCEGFRABL1KDM4EALDH1A1 | |
| SCHEMBL21731040 | 0.74 | SRC (0.38) | SRCEGFRABL1KDM4EALDH1A1 | |
| SCHEMBL10430710 | 0.74 | KDM5A (0.37) | SRCEGFRABL1KDM4EALDH1A1 | |
| SCHEMBL11151560 | 0.73 | KDM5A (0.40) | SRCEGFRABL1KDM4EALDH1A1 | |
| SCHEMBL9381563 | 0.73 | ADORA2A (0.35) | SRCEGFRABL1KDM4EALDH1A1 | |
| SCHEMBL21731050 | 0.69 | ADORA2A (0.64) | KDM4EMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL21731009 | 0.69 | ADORA2A (0.44) | MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL11060121 | 0.68 | RAD52 (0.39) | KDM4EALDH1A1FYNMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0374914-B1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | SEARLE & CO (US) | 1994-04-20 | — | — | EP | claimed |
| EP-0374914-A1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | G.D. Searle & Co. (US) | 1990-06-27 | — | — | EP | claimed |
| US-4866063-A | Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines | G. D. SEARLE & CO. (US) | 1989-09-12 | — | — | US | claimed |
| EP-0374914-B1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | SEARLE & CO (US) | 1994-04-20 | — | — | EP | disclosed |
| EP-0374914-A1 | Diol metabolites of 7-phenyl-1,2,4-triazolo[1,5-c]-pyrimidines-5-amines | G.D. Searle & Co. (US) | 1990-06-27 | — | — | EP | disclosed |
| US-4866063-A | Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines | G. D. SEARLE & CO. (US) | 1989-09-12 | — | — | US | disclosed |