Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL81598 | 0.82 | CA12 (0.52) | ALDH1A1KMT2AMEN1TDP1POLB | |
| SCHEMBL31267166 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KMT2ATDP1CYP1A2 | |
| SCHEMBL13389659 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KMT2ATDP1CYP1A2 | |
| SCHEMBL2268878 | 0.79 | TSHR (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL13151966 | 0.79 | ACHE (0.41) | KMT2ATDP1NPSR1 | |
| SCHEMBL12714916 | 0.78 | ATM (0.63) | ALDH1A1KMT2AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL29953400 | 0.78 | ATM (0.63) | ALDH1A1KMT2AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL279656 | 0.78 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL13389463 | 0.77 | PARP1 (0.33) | TDP1 | |
| SCHEMBL12205536 | 0.76 | GSK3B (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217951-A1 | Metabotropic Glutamate Receptor Negative Allosteric Modulators (NAMS) and Uses Thereof | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170073314-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2017-03-16 | — | — | US | disclosed |
| US-8871796-B2 | Diaryl ether derivatives as notch sparing gamma secretase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-10-28 | — | — | US | disclosed |
| US-8404685-B2 | Dihydropyrazole derivatives as tyrosine kinase modulators for the treatment of tumors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20130053386-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME LLC | 2013-02-28 | — | — | US | disclosed |
| US-8313814-B2 | Cellulose acylate film, method of producing the same, cellulose derivative film, optically compensatory film using the same, optically-compensatory film incorporating polarizing plate, polarizing plate and liquid crystal display device | FUJIFILM CORPORATION (JP) | 2012-11-20 | — | — | US | disclosed |
| US-8221855-B2 | Cellulose derivative film, optical compensation film, polarizing plate, and liquid crystal device | FUJIFILM CORPORATION (JP) | 2012-07-17 | — | — | US | disclosed |
| US-8043714-B2 | Transparent thermoplastic film and a method of producing the same | FUJIFILM CORPORATION (JP) | 2011-10-25 | — | — | US | disclosed |
| US-7993562-B2 | Method of producing a thermoplastic film | FUJIFILM CORPORATION (JP) | 2011-08-09 | — | — | US | disclosed |
| US-7981488-B2 | Liquid crystal display device | FUJIFILM CORPORATION (JP) | 2011-07-19 | — | — | US | disclosed |
| US-20090021673-A1 | Liquid Crystal Display Device | FUJIFILM CORPORATION (JP) | 2009-01-22 | — | — | US | disclosed |
| US-7452897-B2 | Use of substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives for the treatment of neurodegenerative diseases | SANOFI-AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| US-20080075719-A1 | Method for Augmenting B Cell Depletion | GENENTECH, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-7332233-B2 | Iridium compound and organic electroluminescent device using the same | SAMSUNG SDI CO., LTD. (KR) | 2008-02-19 | — | — | US | disclosed |
| US-20070290168-A1 | Resin film, production method thereof, polarizing plate and liquid crystal display device | FUJIFILM CORPORATION (JP) | 2007-12-20 | — | — | US | disclosed |
| US-20070286998-A1 | Method of producing transparent thermoplastic film and transparent thermoplastic film | FUJIFILM CORPORATION (JP) | 2007-12-13 | — | — | US | disclosed |
| US-20070281112-A1 | Thermoplastic film and method of producing the same, polarizing plate, optical compensation film, antireflection film and liquid-crystal display device | FUJIFILM CORPORATION (JP) | 2007-12-06 | — | — | US | disclosed |
| US-20070275183-A1 | Transparent thermoplastic film and a method of producing the same | FUJIFILM CORPORATION (JP) | 2007-11-29 | — | — | US | disclosed |
| US-20070167455-A1 | USE OF SUBSTITUTED 2-(DIAZA-BICYCLO-ALKYL)-PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI-AVENTIS (FR) | 2007-07-19 | — | — | US | disclosed |
| US-7211581-B2 | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives | SANOFI-AVENTIS (FR) | 2007-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217951-A1 | Metabotropic Glutamate Receptor Negative Allosteric Modulators (NAMS) and Uses Thereof | GRM3, GRM2, GRM1 | ALDH1A1 4541/4885KMT2A 942/4885MEN1 2740/4885 |
| US-20170073314-A1 | HUMAN PLASMA KALLIKREIN INHIBITORS | KLKB1, KLK1, KLK5 | ALDH1A1 1065/4885KMT2A 2113/4885MEN1 519/4885 |
| US-20080075719-A1 | Method for Augmenting B Cell Depletion | CD22, ITGAM, FCGR3B | ALDH1A1 1424/4885KMT2A 2362/4885MEN1 3170/4885 |
| US-20130053386-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | BACE1, BACE2, GSAP | ALDH1A1 2490/4885KMT2A 1364/4885MEN1 2290/4885 |
| US-20070167455-A1 | USE OF SUBSTITUTED 2-(DIAZA-BICYCLO-ALKYL)-PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PSEN2, PSEN1, GSK3A | ALDH1A1 322/4885KMT2A 1201/4885MEN1 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.