Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10443533 | 0.89 | LMNA (0.54) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL8391300 | 0.83 | PPARG (0.69) | ALDH1A1 | |
| SCHEMBL10443491 | 0.82 | TNF (0.68) | LMNASMN1; SMN2TP53HTTL3MBTL1 | |
| SCHEMBL10443449 | 0.81 | RAB9A (0.66) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL9040448 | 0.81 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2TP53HPGDDRD2 | |
| SCHEMBL10443034 | 0.80 | TP53 (0.73) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL10443752 | 0.80 | TP53 (0.51) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL10443392 | 0.80 | PPARG (0.72) | — | |
| SCHEMBL8393289 | 0.78 | PPARG (0.52) | TP53DRD2TBXA2RL3MBTL1NPC1 | |
| SCHEMBL10443931 | 0.78 | HDAC1 (0.58) | LMNAMAPTSMN1; SMN2TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |