Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10443531 | 0.89 | LMNA (0.55) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL10443492 | 0.83 | TNF (0.67) | LMNASMN1; SMN2TP53HTTL3MBTL1 | |
| SCHEMBL8391300 | 0.82 | PPARG (0.69) | ALDH1A1 | |
| SCHEMBL10443451 | 0.82 | RAB9A (0.64) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL9040448 | 0.80 | SMN1; SMN2 (0.56) | LMNASMN1; SMN2TP53HPGDDRD2 | |
| SCHEMBL10443754 | 0.79 | ALDH1A1 (0.49) | LMNASMN1; SMN2TP53HTTL3MBTL1 | |
| SCHEMBL10443037 | 0.79 | ALDH1A1 (0.72) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL10443933 | 0.79 | HDAC1 (0.57) | LMNAMAPTSMN1; SMN2TP53HTT | |
| SCHEMBL8393289 | 0.78 | PPARG (0.52) | TP53DRD2TBXA2RL3MBTL1NPC1 | |
| SCHEMBL9041639 | 0.77 | SMN1; SMN2 (0.52) | LMNAMAPTSMN1; SMN2HPGDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392317-A2 | Benzimidazoles, drugs containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1990-10-17 | — | — | EP | disclosed |