SCHEMBL10457794

SCHEMBL10457794

CC(C)C(=O)Nc1nc2c(ncn2[C@@H]2O[C@@H]3CO[Si](C(C)C)(C(C)C)O[Si](C(C)C)(C(C)C)OC3[C@@H]2O)c(=O)[nH]1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 1/20 0.47
▸ TAS1R3 Q7RTX0 1/20 0.46
▸ TAS1R1 Q7RTX1 1/20 0.46
▸ STING1 Q86WV6 12/20 0.44
▸ PDE3B Q13370 1/20 0.44
▸ PDE3A Q14432 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.43
▸ MEN1 O00255 1/20 0.42
▸ KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25496217 1.00 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL19509409 1.00 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL18954971 1.00 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL1936920 1.00 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL19880310 1.00 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL19502688 0.93 TAS1R3 (0.46) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL19502422 0.93 TAS1R3 (0.46) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL25496214 0.92 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL23350694 0.92 KDM4E (0.47) KDM4ETAS1R3TAS1R1STING1PDE3B
SCHEMBL19491657 0.88 KDM4E (0.44) KDM4ETAS1R3TAS1R1STING1PDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230357767-A1 NOVEL NUCLEIC ACID MOLECULE INHIBITING EXPRESSION OF TARGET GENE BONAC CORPORATION (JP) 2023-11-09 — — US disclosed
US-20230183283-A1 NOVEL GLYCOSIDE COMPOUND AND PRODUCTION METHOD THEREFOR BONAC CORPORATION (JP) 2023-06-15 — — US disclosed
US-20180186826-A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS AGILENT TECHNOLOGIES, INC. 2018-07-05 — — US disclosed
US-9896472-B2 Protected monomer and method of final deprotection for RNA synthesis AGILENT TECHNOLOGIES, INC. (US) 2018-02-20 — — US disclosed
US-9273086-B2 Protected monomer and method of final deprotection for RNA synthesis AGILENT TECHNOLOGIES, INC. (US) 2016-03-01 — — US disclosed
US-9273086-B2 Protected monomer and method of final deprotection for RNA synthesis AGILENT TECHNOLOGIES, INC. (US) 2016-03-01 — — US disclosed
US-20160002282-A1 Protected Monomer and Method of Final Deprotection for RNA Synthesis AGILENT TECHNOLOGIES, INC. 2016-01-07 — — US disclosed
US-20160002282-A1 Protected Monomer and Method of Final Deprotection for RNA Synthesis AGILENT TECHNOLOGIES, INC. 2016-01-07 — — US disclosed
US-20120289691-A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS AGILENT TECHNOLOGIES, INC. (US) 2012-11-15 — — US disclosed
US-20120184724-A1 PROTECTED MONOMERS AND METHODS OF DEPROTECTION FOR RNA SYNTHESIS AGILENT TECHNOLOGIES, INC. (US) 2012-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230357767-A1 NOVEL NUCLEIC ACID MOLECULE INHIBITING EXPRESSION OF TARGET GENE SNRPE, DDX21, DCLRE1B KDM4E 3823/4885TAS1R3 2352/4885TAS1R1 1847/4885
US-20230183283-A1 NOVEL GLYCOSIDE COMPOUND AND PRODUCTION METHOD THEREFOR SLC5A11, POLRMT, MAPK11 KDM4E 3480/4885TAS1R3 3998/4885TAS1R1 3287/4885
US-20120289691-A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS NSUN2, SNRPB2, RNGTT KDM4E 1268/4885TAS1R3 4231/4885TAS1R1 4165/4885
US-20180186826-A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS NSUN2, RNGTT, RNMT KDM4E 2664/4885TAS1R3 4261/4885TAS1R1 4266/4885
US-20160002282-A1 Protected Monomer and Method of Final Deprotection for RNA Synthesis NSUN2, SNRPB2, RNGTT KDM4E 1268/4885TAS1R3 4231/4885TAS1R1 4165/4885
US-20120184724-A1 PROTECTED MONOMERS AND METHODS OF DEPROTECTION FOR RNA SYNTHESIS RNMT, RNGTT, NSUN2 KDM4E 3200/4885TAS1R3 3654/4885TAS1R1 3731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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