SCHEMBL10464296

SCHEMBL10464296

Clc1[nH]c2cccc(Cl)c2c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.46
ERCC5 P28715 1/20 0.46
FEN1 P39748 1/20 0.46
GPR84 Q9NQS5 1/20 0.42
GAA P10253 1/20 0.42
GRIN2D O15399 2/20 0.42
GRIN3B O60391 2/20 0.42
GRIN1 Q05586 2/20 0.42
GRIN2A Q12879 2/20 0.42
GRIN2B Q13224 2/20 0.42
GRIN2C Q14957 2/20 0.42
GRIN3A Q8TCU5 2/20 0.42
PSMB8 P28062 4/20 0.41
CHEK1 O14757 1/20 0.40
GPR17 Q13304 1/20 0.39
PBRM1 Q86U86 1/20 0.39
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
GABRA1 P14867 1/20 0.39
GABRB1 P18505 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31619545 0.83 ERCC5 (0.53) DYRK1AERCC5FEN1GPR84GAA
SCHEMBL6009055 0.83 ERCC5 (0.53) DYRK1AERCC5FEN1GPR84GAA
SCHEMBL20276479 0.78 ERCC5 (0.50) DYRK1AERCC5FEN1GPR84GAA
SCHEMBL8900692 0.78 ERCC5 (0.40) DYRK1AERCC5FEN1GPR84GAA
SCHEMBL8219938 0.74 ERCC5 (0.44) DYRK1AERCC5FEN1GPR84GAA
SCHEMBL29954948 0.74 MEN1 (0.52) DYRK1AERCC5FEN1GPR84GAA
SCHEMBL9038402 0.72 GPR17 (0.61) ERCC5FEN1GRIN2DGRIN3BGRIN1
SCHEMBL31332450 0.72 GPR17 (0.61) ERCC5FEN1GRIN2DGRIN3BGRIN1
SCHEMBL7673751 0.71 GPR17 (0.49) ERCC5FEN1GAAGRIN2DGRIN3B
SCHEMBL9272732 0.71 GPR17 (0.60) ERCC5FEN1GRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118459388-B Indole benzoquinone derivative and preparation method and application thereof 四川大学 2024-09-03 CN claimed
CN-118459388-A Indole benzoquinone derivative and preparation method and application thereof 四川大学 2024-08-09 CN claimed
CN-108828110-B Method for determining residual quantity of benzimidazole drugs in chicken fat 广东出入境检验检疫局检验检疫技术中心 2021-09-21 CN claimed
CN-109001334-B Method for measuring residual quantity of benzimidazole drugs in chicken tissues 广东出入境检验检疫局检验检疫技术中心 2021-04-27 CN claimed
JP-2290877-A None JP disclosed
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS UNIV DANMARKS TEKNISKE (DK) 2025-11-20 US disclosed
EP-4526426-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS Danmarks Tekniske Universitet (DK) 2025-03-26 EP disclosed
CN-118459388-B Indole benzoquinone derivative and preparation method and application thereof 四川大学 2024-09-03 CN disclosed
CN-118459388-A Indole benzoquinone derivative and preparation method and application thereof 四川大学 2024-08-09 CN disclosed
WO-2023222879-A2 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS DANMARKS TEKNISKE UNIVERSITET (DK) 2023-11-23 WO disclosed
CN-111989328-B Heterocyclic derivatives as pest control agents 拜耳公司 2023-04-18 CN disclosed
CN-115803036-A Use of extracellular vesicles as immunoprophylactic and immunotherapeutic agents for leishmaniasis 耶迪特普大学 2023-03-14 CN disclosed
CN-111433215-A Derivatives of heterocyclic compounds as pest control agents 拜耳公司 2020-07-17 CN disclosed
CN-111132549-A Long-acting control agent for ectoparasites of animals 三井化学AGRO株式会社 2020-05-08 CN disclosed
CN-111132977-A Quinoline derivatives for the treatment of helminth infections 拜耳动物保健有限责任公司 2020-05-08 CN disclosed
CN-111108106-A Heterocyclic derivatives as pest control agents 拜耳公司 2020-05-05 CN disclosed
CN-110869349-A 2- { [2- (phenoxymethyl) pyridin-5-yl ] oxy } ethanamine derivatives and related compounds as pest control agents, e.g. for protecting plants 拜耳作物科学股份公司 2020-03-06 CN disclosed
CN-110770227-A Novel azaquinoline derivatives 拜耳动物保健有限责任公司 2020-02-07 CN disclosed
CN-110691781-A Mesoionic imidazopyridines as pesticides 拜耳公司 2020-01-14 CN disclosed
JP-H02290877-A 1-(3-DIETHYLAMINOPROPYL)AMINO-5-METHYLDIPYRIDO (4,3-B) (3,4-F1 INDOLE TRIHYDROCHLORIDE SANOFI SA 1990-11-30 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250354108-A1 METHODS FOR PRODUCING MONOTERPENE INDOLE ALKALOIDS INMT, KARS1, MIA3 DYRK1A 1903/4885ERCC5 2359/4885FEN1 1031/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.