Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5666588 | 0.78 | CA12 (0.44) | MEN1ALDH1A1KMT2ATDP1GRIN2D | |
| SCHEMBL31619545 | 0.75 | ERCC5 (0.53) | ERCC5FEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6009055 | 0.75 | ERCC5 (0.53) | ERCC5FEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL29954948 | 0.74 | MEN1 (0.52) | ERCC5FEN1MEN1ALDH1A1KMT2A | |
| SCHEMBL10464296 | 0.74 | DYRK1A (0.46) | ERCC5FEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL1336656 | 0.73 | KIF11 (0.46) | MEN1ALDH1A1KMT2AGAA | |
| SCHEMBL29953769 | 0.73 | KIF11 (0.46) | MEN1ALDH1A1KMT2AGAA | |
| SCHEMBL7493525 | 0.71 | ALDH1A1 (0.48) | ERCC5FEN1MEN1ALDH1A1KMT2A | |
| SCHEMBL20276479 | 0.71 | ERCC5 (0.50) | ERCC5FEN1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9038402 | 0.69 | GPR17 (0.61) | ERCC5FEN1ALDH1A1GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000071524-A1 | 2-NH-PYRIDONES AND PYRIMIDONES AS MRS INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-30 | — | — | WO | disclosed |