Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468074 | 0.80 | MEN1 (0.51) | KDM1AMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL10468073 | 0.80 | MEN1 (0.51) | KDM1AMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL10469701 | 0.80 | MEN1 (0.51) | KDM1AMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL10468698 | 0.80 | MEN1 (0.51) | KDM1AMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL12871712 | 0.76 | GRIN2B (0.52) | KDM1AMEN1KMT2AADAM17ALDH1A1 | |
| SCHEMBL10467519 | 0.76 | KDM1A (0.50) | KDM1APOLBSMN1; SMN2SLC6A4SLC6A2 | |
| SCHEMBL23712301 | 0.74 | LMNA (0.39) | KDM1AALDH1A1 | |
| SCHEMBL10467584 | 0.74 | LMNA (0.39) | KDM1AALDH1A1 | |
| SCHEMBL11075149 | 0.72 | CYP19A1 (0.50) | KDM1AMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL8064644 | 0.72 | KDM1A (0.46) | KDM1AMEN1KMT2ASMN1; SMN2ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4927826-A | Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists | HOFFMAN-LA ROCHE INC. (US) | 1990-05-22 | — | — | US | disclosed |
| US-4786646-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-22 | — | — | US | disclosed |