SCHEMBL10469339

SCHEMBL10469339

Nc1ccc2c(c1)sc1cc(F)ccc12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.62
ALDH1A1 P00352 4/20 0.62
RAB9A P51151 4/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
HPGD P15428 1/20 0.62
APP P05067 3/20 0.45
GFER P55789 2/20 0.44
AXL P30530 1/20 0.44
BCKDK O14874 1/20 0.42
LMNA P02545 2/20 0.40
POLB P06746 1/20 0.40
MMP12 P39900 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
KDM4E B2RXH2 2/20 0.37
PKM P14618 1/20 0.37
ALOX12 P18054 1/20 0.37
MAPK1 P28482 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
NPC1 O15118 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30785527 0.87 MAPT (0.78) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL30267589 0.87 MAPT (0.78) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL204571 0.87 MAPT (0.78) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
Hydrochloric Acid SCHEMBL7056525 0.84 MAPT (0.75) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL18965676 0.82 MAPT (0.72) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL11707874 0.79 RAB9A (0.47) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL31238914 0.78 MAPT (0.73) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL3480951 0.78 MAPT (0.73) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL24254893 0.77 MAPT (0.64) MAPTALDH1A1RAB9ASMN1; SMN2HPGD
SCHEMBL2343867 0.77 ALDH1A1 (1.00) MAPTALDH1A1RAB9ASMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4965284-A IMMUNOMODULATORS AMERICAN CYANAMID COMPANY (US) 1990-10-23 US disclosed
EP-0342433-A2 Substituted dibenzothiaphenes AMERICAN CYANAMID COMPANY (US) 1989-11-23 EP disclosed