Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL10469482 | 0.79 | CYP3A4 (0.46) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| Nitric Acid SCHEMBL10469480 | 0.76 | HIF1A (0.58) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| SCHEMBL28197166 | 0.73 | CYP2D6 (0.43) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| Nitric Acid SCHEMBL10469484 | 0.69 | HIF1A (0.40) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| SCHEMBL6819687 | 0.68 | RAB9A (0.38) | HIF1ATSHRCYP2D6CYP2C19MAPT | |
| SCHEMBL3494064 | 0.68 | TSHR (0.52) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| SCHEMBL11534642 | 0.65 | TDP1 (0.46) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| Nitric Acid SCHEMBL11289809 | 0.64 | HIF1A (0.50) | HIF1ATSHRCYP2D6CYP2C19LMNA | |
| Hydrochloric Acid SCHEMBL11260141 | 0.63 | KCNH2 (0.39) | HIF1ATSHRCYP2D6CYP2C19 | |
| Nitric Acid SCHEMBL11013104 | 0.63 | LMNA (0.48) | HIF1ATSHRCYP2D6CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4965277-A | Fungicides | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1990-10-23 | — | — | US | disclosed |